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Simulated changes in tmax (blue line) based on changes in MAT ranging from 10.1 to 3 hr for (A) a one-compartment drug with an elimination half-life of 4 hr following a single dose (Eq. 4) and (B) a drug dosed to steady-state with an elimination half-life of 4 hr and dosing interval of 6 hr. Horizontal (red) lines indicate the impact of 15 min changes in MAT on tmax (y-axis) for a rapidly absorbed drug (MAT = 0.5 hr) versus a less-rapidly absorbed drug (MAT = 2 hr)
