Table VI:
Regional Expression of Clinically Significant Efflux and Uptake Transporters in the Intestine, Liver, Kidney and Brain
| Transporter Type | Transporter | Intestinal Localization | Hepatic Localization | Renal Localization | Brain Localization |
|---|---|---|---|---|---|
| Efflux | BCRP | Apical | Bile Canaliculi | Apical (Blood) | |
| MDR1 (P-gp) | Apical | Bile Canaliculi | Apical (Urine) | Apical (Blood) | |
| MRP2 | Apical | Bile Canaliculi | Apical (Urine) | ||
| MRP3 | Basolateral | Sinusoidal (Basolateral) | |||
| THTR1 | Basolateral | Basolateral | |||
| BSEP | Bile Canaliculi | ||||
| MDR3 | Bile Canaliculi | ||||
| MATE1 | Bile Canaliculi | Apical (Urine) | |||
| MATE2-K | Apical (Urine) | ||||
| MRP4 | Sinusoidal (Basolateral) | Apical (Urine) | Apical (Blood) | ||
| MRP6 | Sinusoidal (Basolateral) | ||||
| Uptake | OATP2B1 | Apical | Sinusoidal (Basolateral) | ||
| ASBT | Apical | ||||
| MCT1 | Apical | ||||
| PEPT1/PEPT2 | Apical | Apical (Urine) | |||
| THTR2 | Apical | Apical (Urine) | |||
| OCT1 | Sinusoidal (Basolateral) | ||||
| OAT2 | Sinusoidal (Basolateral) | Basolateral | |||
| OAT7 | Sinusoidal (Basolateral) | ||||
| OATP1A2 | Apical (Blood) | ||||
| OATP1B1 | Sinusoidal (Basolateral) | ||||
| OATP1B3 | Sinusoidal (Basolateral) | ||||
| NTCP | Sinusoidal (Basolateral) | ||||
| OAT1/3 | Basolateral | ||||
| OATP4C1 | Basolateral | ||||
| OCT2 | Basolateral | ||||
| URAT1 | Apical (Urine) | ||||
| Bidirectional | OSTα/β | Basolateral | Sinusoidal (Basolateral) | ||
| ENT1 | Basolateral | Bile Canaliculi Sinusoidal (Basolateral) | Apical (Urine) | Basolateral (Brain) | |
| ENT2 | Basolateral | Sinusoidal (Basolateral) | Basolateral | Basolateral (Brain) Apical (Blood) | |
| OAT4 | Apical | ||||
| OCTN1/2 | Apical (Urine) |