TABLE 1.

Previous reports of association between the six sequenced genes and psychiatric phenotypes, including response to mediation.

Genes	Variants	Associated phenotypes	References
GSK3B	rs6438552	Brain structural changes in major depressive disorder (MDD)	Inkster et al., 2009
	rs6438552 rs334558	Age of onset of bipolar disorder (BD) in female patients Response to lithium treatment	Lin et al., 2013
	Haplotype containing rs334558 and rs3755557	Response to lithium treatment	Iwahashi et al., 2014
	rs334558	Response to lithium augmentation	Adli et al., 2007
	rs334558	Gray matter volumes in the right frontal lobe of patients with BD	Benedetti et al., 2015
	rs334558	Remission in patients with depressive disorders	Levchenko et al., 2018
	rs334558, rs13321783, rs2319398	Response to antidepressant therapy	Tsai et al., 2008
	rs12630592	Severity of mania (in both acute and stabilized periods) and depression in stabilized periods	Bureau et al., 2017
	Haplotype containing rs334555, rs119258668, and rs11927974	Age of onset of MDD	Saus et al., 2010
	Interaction of rs6782799, rs6265 (BDNF), and negative life events	MDD	Yang et al., 2010
BDNF	rs6265	MDD	Tsai et al., 2003; Schroter et al., 2020
	Interaction of rs6265 and stressful life events	MDD	Hosang et al., 2014
	rs6265	Recurrent MDD	Xiao et al., 2011; Lee Y. et al., 2013
	rs6265	Severity of depression	Losenkov et al., 2020
	rs6265	Response to antidepressant therapy and remission in MDD	Choi et al., 2006; Alexopoulos et al., 2010; Chi et al., 2010; Zou et al., 2010; Taylor et al., 2011; Murphy et al., 2013; Wang et al., 2014; Colle et al., 2015; Xin et al., 2020
	rs712442	Response to antidepressant therapy	Ochi et al., 2019
NGF	Haplotype containing rs2254527, rs6678788, and rs12760036	Remission rate in MDD	Yeh et al., 2015
	Interaction with BDNF, among 590 other polygenes	Suicide attempt	Sokolowski et al., 2016
NRG1	rs4733272 (together with other chromosome 8-associated SNPs)	Schizophrenia, BD and MDD	Chen et al., 2017
	rs4236710 and rs4512342; haplotype containing rs4512342 and rs6982890 rs2919375 Haplotype containing rs4531002 and rs11989919	Schizophrenia MDD MDD and BD	Wen et al., 2016
	rs35753505 and rs7014762	BD	Mei and Nave, 2014
	rs6994992, rs2439272, rs62510682, rs10503929, and rs3924999	Prepulse inhibition (PPI, a measure of inhibitory sensorimotor gating)	Hong et al., 2008; Roussos et al., 2011
	rs6994992	Activity of frontal and temporal lobes, premorbid IQ, and positive symptoms in schizophrenia	Hall et al., 2006; Papiol et al., 2011
	rs3924999	Perceptual aberrations in schizotypal personality disorder	Lin et al., 2005
HTR2C	rs6318	Severity of depression	Brummett et al., 2014
	rs6318	Response to antidepressant therapy	Vyalova et al., 2017
	rs6318	Suicide attempt	Karanovic et al., 2015
	rs6318	Dysregulated stress responding and risk for depression	Avery and Vrshek-Schallhorn, 2016
	rs6318	Stress-induced mesoaccumbal dopamine release	Mickey et al., 2012
	rs6318 and rs3813929	Feeding behavior and antipsychotics-induced weight gain and movement disorders	Drago and Serretti, 2009
	rs1414334	Metabolic syndrome in patients using antipsychotics	Mulder et al., 2009; Risselada et al., 2012
PIP4K2A	rs10828317	Tardive dyskinesia in schizophrenia patients	Fedorenko et al., 2014
	rs10828317	Schizophrenia	Schwab et al., 2006; Bakker et al., 2007; Fedorenko et al., 2013
	rs10828317 and rs10430590	CGI-S total score at day 28 of antidepressant therapy	Vyalova et al., 2017
	rs11013052	Schizophrenia	Saggers-Gray et al., 2008
	rs8341	Schizophrenia	He et al., 2007
	Various intronic deletions and insertions 29 bp from the exon 9–intron 9 junction	BD	Stopkova et al., 2003