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. Author manuscript; available in PMC: 2020 Sep 8.
Published in final edited form as: N Engl J Med. 2015 Jul 2;373(1):35–47. doi: 10.1056/NEJMoa1414799

Figure 3. Temporal Profile of Mutations Detected by WES.

Figure 3.

(A-C) Representative secular analysis of somatic mutations and the relationship with peripheral blood counts and response to immunosuppressive therapy. Each case represents blood counts (upper panel) and variant allele frequency of mutations identified by whole exome sequencing (lower panel). Treatment received is shown at the bottom of each panel (CsA = cyclosporine and h/rATG = horse/rabbit antithymocyte globulin). Asterisks indicate the samples not subjected to whole exome sequencing. (D) Chronological history of clonal evolution from the onset to the last follow-up in NIH075. Each mutated gene is depicted in the representative cells. Vertical axis indicates the absolute volume of the clones. Representative mutations in each clone are also presented.