Variant allele frequency of mutations in frequently affected genes such as (A) BCOR/BCORL1, (B) PIGA, (C) DNMT3A, (D) ASXL1, are plotted for all relevant mutations. Each line indicates the time course of VAFs for an individual mutation and response at 6 months was used to identify complete responders (CR-blue), partial responders (PR-green), and non-responders (NR-red) to immunosuppressive therapy.