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. Author manuscript; available in PMC: 2020 Sep 8.
Published in final edited form as: N Engl J Med. 2015 Jul 2;373(1):35–47. doi: 10.1056/NEJMoa1414799

Figure 4. Temporal Profile of Common Mutations in the NIH Cohort.

Figure 4.

Variant allele frequency of mutations in frequently affected genes such as (A) BCOR/BCORL1, (B) PIGA, (C) DNMT3A, (D) ASXL1, are plotted for all relevant mutations. Each line indicates the time course of VAFs for an individual mutation and response at 6 months was used to identify complete responders (CR-blue), partial responders (PR-green), and non-responders (NR-red) to immunosuppressive therapy.