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. 2020 Sep 8;15(9):e0238794. doi: 10.1371/journal.pone.0238794

Table 3. Cox proportional hazards regression analysis of time to HIV testing among sexual contacts of HIV-positive index clients in Siaya County, Kenya.

Time to Testing Univariable Multivariable (Main Model) Multivariable (Time-Varying Covariate)*
HR (95% CI) P value aHR (95% CI) P value aHR (95% CI) P value
Age, years§
18–24 1.32 (1.15–1.51) <0.001 1.32 (1.01–1.73) 0.04 0.94 (0.87–1.02) 0.153
25–34 1.14 (1.04–1.24) 0.005 1.18 (1.01–1.39) 0.038 0.96 (0.9–1.01) 0.126
35–44 Ref Ref Ref
≥45 1.03 (0.89–1.18) 0.727 0.96 (0.79–1.18) 0.727 1.02 (0.95–1.11) 0.54
Sex
Female 1.10 (1–1.2) 0.04 0.95 (0.81–1.1) 0.496 - -
Male Ref Ref
Marital Status§^
Married Monogamous Ref Ref Ref
Married Polygamous 0.93 (0.73–1.17) 0.527 0.78 (0.54–1.12) 0.174 1.12 (1.01–1.25) 0.039
Single 1.58 (1.25–2) <0.001 0.71 (0.51–1) 0.05 1.17 (1.08–1.27) <0.001
Unknown 1.18 (0.98–1.41) 0.079 0.43 (0.3–0.64) <0.001 1.25 (1.14–1.38) <0.001
Widowed 1.18 (0.77–1.81) 0.456 0.71 (0.29–1.74) 0.459 1.08 (0.82–1.42) 0.588
Relationship to Index Client§^
Non-spouse Sexual Contact 1.68 (1.44–1.96) <0.001 1.12 (0.84–1.48) 0.444 1.23 (1.15–1.32) <0.001
Spouse Ref Ref Ref
Sub-County§
Alego Usonga 1.49 (1.07–2.08) 0.019 1.90 (1.14–3.17) 0.014 0.90 (0.77–1.05) 0.186
Bondo 1.42 (1.02–1.97) 0.037 1.47 (0.92–2.35) 0.11 0.95 (0.82–1.09) 0.449
Gem 1.28 (0.98–1.67) 0.067 1.06 (0.73–1.54) 0.755 1.09 (0.93–1.28) 0.27
Rarieda 1.65 (1.24–2.18) 0.001 1.39 (0.9–2.15) 0.14 1.07 (0.91–1.25) 0.425
Ugenya Ref Ref Ref
Ugunja 1.15 (0.82–1.61) 0.417 0.71 (0.4–1.26) 0.242 1.20 (1.01–1.42) 0.038

*Time-varying covariate interacted with natural logarithm of time

§Violated proportional hazards assumptions and was included as a time-varying covariate in Cox model

^Significant time-varying covariate interaction

Abbreviations: HR, hazards ratio; CI, confidence interval; aHR, adjusted hazards ratio.