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. 2020 Sep 8;18(9):e3000849. doi: 10.1371/journal.pbio.3000849

Fig 5. Age and sex cause differences in gene expression upon SARS-CoV-2 infection.

Fig 5

(A) N1 Ct values by age group. No significant differences between were observed by Kruskal-Wallis ANOVA. (B) N1 Ct values by sex. No significant difference between groups was observed by t test. (C) Gene expression differences by age and viral load. Significance by Mann Whitney U test between SARS-CoV-2-positive samples aged >60 and <60 is shown, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. (D) Sex-modulated DE genes (padj < 0.1) upon SARS-CoV-2 infection. Genes elevated in females are shown as negative log2 fold changes, and those elevated in males as positive log2 fold changes. Raw data available in the GEO Repository, accession GSE152075. Ct, cycle threshold; DE, differentially expressed; GEO, Gene Expression Omnibus; N1, SARS-CoV-2 nucleocapsid gene region 1; NK, natural killer; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.