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. 2020 Jun 5;217(9):e20192152. doi: 10.1084/jem.20192152

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© 2020 Ningbo University

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Figure 1. — Sera from JEV-exposed humans and mice contain JEV-EDIII- and ZIKV-EDIII-reactive IgG. (A–C) Human serum samples were prepared from JEV-naive 6-mo-old infants (n = 8) or JEV-naive, JEV-vaccinated children or young adults aged 7 (n = 6), 8 (n = 6), 9 (n = 6), 10 (n = 6), 11 (n = 6), and 20 (n = 6) yr. (D and E) Mouse serum samples were prepared from JEV-naive (mock-immune, n = 8) and JEV-immune (n = 8) mice. Mouse anti-His mAb was used as positive control (n = 6). JEV-EDIII– and ZIKV-EDIII–reactive IgG levels were measured by indirect ELISA. Data are presented as the mean ± SEM. *, P < 0.05; **, P < 0.01 by two-tailed Mann–Whitney U test.