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. 2020 Jun 5;217(9):e20192152. doi: 10.1084/jem.20192152

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© 2020 Ningbo University

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Figure S1. — Modest neutralization but efficient enhancement of ZIKV infection in vitro by JEV-neutralizing, JEV-immune sera from humans and mice. (A–D) Human serum samples isolated from JEV-naive infants (6 mo of age, n = 6) or JEV-immune subjects (n = 6 for all age groups), and mouse serum samples (n = 6 for all groups) were tested for neutralization of ZIKV (A and B) or JEV (C and D) infection of Vero cells. Mouse ZIKV-immune serum was used as the positive control. (E and F) Enhancement of ZIKV infection by JEV-immune sera from humans and mice was evaluated in U937 cells. Data are expressed as the mean ± SEM.