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. 2020 Jun 15;217(9):e20192080. doi: 10.1084/jem.20192080

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© 2020 Mahuron et al.

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Figure 4. — Expression of layilin promotes the accumulation of cytotoxic CD8⁺ T cells in tumors. (A) Competitive adoptive transfer tumor model to elucidate layilin activity on TILs in vivo. (B–H) 2 and 3 wk following MC38 engraftment and T cell adoptive transfer into Rag^−/− hosts, tumor-infiltrating and peripheral T cells were analyzed by flow cytometry. Data are representative of two independent experiments; paired symbols represent individual mice. Statistical significance was determined by unpaired two-tailed t test (D–G); *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. ns, not significant.