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Human layilin can be cross-linked and does not require the talin for localization with LFA-1. (A) LFA-1 activation following addition of full-length anti-layilin or a derivative antigen-binding fragment (Fab). (B) Proximity ligation assay signal intensity of layilin with LFA-1 on Jurkat cells expressing either wild-type human layilin or layilin mutated to truncate the talin-binding domain. Data are representative of two independent experiments; mean and SEM are shown.
