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. 2020 Jun 25;217(9):e20191548. doi: 10.1084/jem.20191548

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© 2020 Lee et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 4. — Protective efficacy of NS1 immunity against a low-passaged DENV2 clinical isolate. IFNAR^−/− mice were immunized with NS1(16681) or OVA as described in the legend of Fig. 1. 8 wk after immunization, mice were s.c. challenged with 10⁵ PFU EHIE2862Y15. (A and B) Systemic sNS1 levels (A) and viremia titers (B) were measured at days 3 and 6 p.i. (n = 5). (C and D) Mice (n = 8) were monitored daily upon challenge. Kaplan–Meier survival curve and weight loss profile are shown. (E) Vascular leakage was assessed in the liver and kidneys at day 4 p.i. (n = 4–5). Data are representative of at least two independent experiments. Data were analyzed by nonparametric Mann–Whitney U test. *, P < 0.05; **, P < 0.01; ns, not significant. Results were expressed as averages ± SD (A, D, and E).