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. 2020 Jul 7;217(9):e20192389. doi: 10.1084/jem.20192389

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© 2020 Oni et al.

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Figure 3. — SOAT1 loss significantly impairs PDAC progression. (A) Proliferation curves of murine M3L organoids with Soat1 WT or KO. Results show mean ± SD of five technical replicates. ***, P < 0.001, unpaired Student’s t test calculated for the last time point. (B) Images of tumors derived from M3L OGO models with Soat1 WT (n = 5) or KO (n = 5) in nu/nu mice on day 48 after transplantation. (C) Quantification of tumor volumes from B. Results show mean ± SEM of five biological replicates per cohort. *, P < 0.05, unpaired Student’s t test. (D) Quantification of mice with metastases for the experiment shown in B. (E) Survival curves of M3L OGO models with Soat1 WT (n = 12) or KO (n = 11) in nu/nu mice. ***, P < 0.001. OS, overall survival. (F) Proliferation curves of M3L organoids with Soat1 WT or KO in complete media containing 50 µM cholesterol. Results show mean ± SD of five technical replicates. ***, P < 0.001, unpaired Student’s t test calculated for the last time point.