Table 1. Distributions of open durations for wild-type α7 nAChR.
[ACh] | Calcium free | 1.8 mM Ca2+ | ||||||
---|---|---|---|---|---|---|---|---|
Mean open, s | Weight | Mean open, s | Weight | |||||
1 µM | 1.2 × 10−5 ± 1.7 × 10−6 | 1.0 | 1.5 × 10−5 ± 3.7 × 10−6 | 1.0 × 10−4 ± 9.7 × 10−6 | 0.67 ± 0.02 | 0.33 ± 0.02 | ||
n = 3 | n = 6 | |||||||
10 µM | 1.0 × 10−5 ± 1.2 × 10−6 | 6.1 × 10−5 ± 6.4 × 10−6 | 0.90 ± 0.03 | 0.10 ± 0.06 | 1.1 × 10−5 ± 1.3 × 10−6 | 1.2 × 10−4 ± 3.4 × 10−5 | 0.58 ± 0.06 | 0.41 ± 0.06 |
n = 6 | n = 4 | n = 4 | ||||||
100 µM | 1.2 × 10−5 ± 1.6 × 10−6 | 8.9 × 10−5 ± 1.6 × 10−6 | 0.55 ± 0.03 | 0.45 ± 0.3 | 1.2 × 10−5 ± 1.7 × 10−6 | 9.5 × 10−5 ± 8.5 × 10−6 | 0.59 ± 0.04 | 0.41 ± 0.04 |
n = 6 | n = 6 |
Time constants and relative weights of exponential components were obtained by fitting open-duration histograms for n experiments.