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. 2020 Sep 8;9:e60692. doi: 10.7554/eLife.60692

Figure 1. PRC exhibits strong rate adaptation in PC model.

(A) Schematic representation of the definition and computation of PRCs. The current pulse has a duration of 0.5 ms and an amplitude of 50 pA. Different spike rates were achieved by somatic current injection (Couto et al., 2015; Phoka et al., 2010). (B) The rate adaptation of the flat part and the phase-dependent PRC peak. (C) PRC peak amplitudes at different firing rates fitted by the Boltzmann function. (D) Duration of the flat phase at different firing rates.

Figure 1.

Figure 1—figure supplement 1 . Rate-dependent PRCs.

Figure 1—figure supplement 1 .

(A) Negative stimulus-triggered responses (phase delay) parallel positive stimuli (see Figure 1). Onset-phases of phase-dependent responses shift left at high rates with gradually larger amplitudes. (B) The PC model with passive dendrites shows similar rate adaptation as in PC models with active dendrites (Figure 1). (C) Larger stimulus amplitudes increase the peak of the phase-dependent PRCs and shift their onset phases to the left. Simulation results at rates of 12-, 27- and 42 Hz are shown with increased stimulus amplitudes from 0.05 nA to 0.25 nA.
Figure 1—figure supplement 2 . Rate-dependent PRCs are influenced by the dendrite.

Figure 1—figure supplement 2 .

PRC obtained in the PC model without its dendrite. (A) The PRC has a different rate adaptation: the peak has a constant width and its amplitude decreases with firing rate. (B) Normalized peak amplitudes at different firing rates. (C) The flat phase has a constant duration.