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. 2020 Aug 8;86(3):347–359. doi: 10.1007/s00280-020-04119-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Dose-normalized C_max for acMMAE; (b) dose-normalized AUC_inf for acMMAE; (c) dose-normalized C_max for MMAE; (d) dose-normalized AUC_inf for MMAE; (e) Dose-normalized C_max for total antibody; (f) dose-normalized AUC_inf for total antibody in Cycle 1 in DCS4968g (NCT01290549) and JO29138 (JAPICCTI‐142580) studies following pola monotherapy, by NCA. Blue triangles represent individual patients from study DCS4968g (NCT01290549; 0.1–2.4 mg/kg), and red circles represent individual patients from study JO29138 (JAPICCTI‐142580; 1.0–1.8 mg/kg). Horizontal lines represent the mean values. acMMAE antibody-conjugated monomethyl auristatin E, AUC_inf area under the concentration–time curve from time 0 to infinity, C_max maximum concentration observed, MMAE monomethyl auristatin E, pola polatuzumab vedotin