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. 2020 Aug 10;86(3):361–374. doi: 10.1007/s00280-020-04122-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Cytotoxic effect of rapamycin alone (RAPA; range from 0.1 to 100 nM) and in combination with methylprednisolone (MP 50 µM) on CCRF-CEM cells. Cells were exposed for 72 h to drugs and cytotoxicity was evaluated by the MTT assay. The value is the percentage of treated cells vs untreated controls. Results are mean values ± SE from three independent experiments; two-way ANOVA (p < 0.0001) and Bonferroni post-test ***p value < 0.001