Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 26;8:856. doi: 10.3389/fcell.2020.00856

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Westmark, Kiso, Halfmann, Westmark and Kawaoka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

SARS-Cov-2 negative sense RNA contains a canonical G-quartet FMRP binding site. FMRP binds to target RNAs via G-quartet cis-regulatory elements through the consensus sequence 5′-DWGG N_(0–2) DWGG N_(0–1) DWGG N_(0–1) DWGG-3′ where D = any nucleotide except C and W = A or U. The whole genome sequence of the Wuhan seafood market pneumonia virus genome assembly (GenBank LR757995.1) contains a canonical G-quartet sequence at nucleotides 6014-5996 of negative sense of SARS-CoV-2 RNA. The corresponding negative sense sequence is: 5′-TTGG-AT-ATGG-TTGG-T-TTGG-3′.