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. 2020 Aug 26;8:856. doi: 10.3389/fcell.2020.00856

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Copyright © 2020 Westmark, Kiso, Halfmann, Westmark and Kawaoka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FMRP is predicted to bind to multiple regions of SARS-CoV-2 RNA. (A) The catRAPID Global Score algorithm with uniform fragmentation and signal localization predicts multiple FMRP binding sites in both positive and negative sense SARS-CoV-2 RNA, with the strongest predicted binding in the region of nucleotides 9,000–17,000 (positive sense) and nucleotides 9,000–15,000 (negative sense). (B) The top specific interactions are graphed by protein/RNA sequence positions (x-axis) versus interaction score (y-axis). Protein and RNA coordinates are reported relative to the NCBI database.