Table 2.
Descriptive statistics of the cohort and parameters of bone health.
| Mean | +/- SD | Range | Male adult normal range | N | |
|---|---|---|---|---|---|
| Age (years) | 11.9 | 4.76 | 2.64–20.9 | 128 | |
| Age at diagnosis (years) | 6.07 | 4.34 | 0.12–16.9 | 128 | |
| Peripheral blasts/μl at diagnosis | 4077 (Median) | 106810 | 0–597870 | 121 | |
| Time from initial diagnosis (years) | 5.88 | 3.75 | 0.59–13.9 | 128 | |
| Height-SDS | −0.37 | 1.28 | −5.78–2.73 | 127 | |
| BMI-SDS | 0.37 | 1.12 | −5.02–2.66 | 127 | |
| Delta bone age—biological age | −0.52 | 1.30 | −4.35–3.09 | 59 | |
| PH-SDS | −0.16 | 0.87 | −2.91–1.99 | 83 | |
| TV/BR-SDS | −0.32 | 1.00 | −3.39–1.79 | 69 | |
| DXA Z | −0.38 | 1.18 | −3.3–2.1 | 55 | |
| HAZ | 0.13 | 1.06 | −3.0–2.8 | 51 | |
| BHI-SDS | −0.86 | 1.12 | −3.1–2.1 | 47 | |
| Serum-Calcium (mmol/l) | 2.42 | 0.10 | 2.21–2.69 | 127 | |
| Serum-Phosphate (mmol/l) | 1.40 | 0.24 | 0.68–2.42 | 127 | |
| 25-OH V D (ng/ml) | 16.3 | 10.6 | 1.85–62.6 | > 10 (35) | 124 |
| 1,25-(OH)2 V D (pg/ml) | 60.9 | 24.3 | 13–158 | 35–90 | 116 |
| TSAP (U/l) | 211 | 98.9 | 37–468 | 25–124 | 127 |
| BAP (U/l) | 126 | 66.2 | 18.3–308 | 22–112 | 123 |
| PTH (pg/ml) | 46.0 | 25.8 | 9.60–160 | 15–65 | 122 |
| NTX (nmolBCE/nmol crea) | 408 | 281 | 21–922 | 34–780 | 31 |
| DPD (μg/g crea) | 147 | 86.4 | 27.3–363 | 110–450 | 69 |
| Ca:Crea (mg/mg) | 0.11 | 0.10 | 0.00–0.50 | 0.03–0.24 (36) | 118 |
| Osteocalcin (ng/ml) | 103 | 63.7 | 11.9–426 | 18.6–71.5 | 79 |
| IGF-1 SDS | −0.30 | 1.19 | −3.55–2.93 | 128 | |
| Vitamin D intake (U/d) | 93.6 | 66 | 1.2–277 | 118 | |
| Calcium intake (mg/d) | 790 | 374 | 170–2247 | 118 | |
| Screen-time (h) | 2.08 | 1.41 | 0–5 | 120 |
Mean, SD, range, male adult normal values and the number of patients examined are displayed. body mass index (BMI) SDS, pubic hair stage (PH) SDS, testicular volume/breast development stage SDS (TV/BR) SDS, dual-energy X-ray absorptiometry (DXA) SDS, Height adjusted Z-scores (HAZ), Bone Health Index (BHI-SDS), 25-OH vitamin D (25-OH VD), serum 1,25-(OH)2 vitamin D (1,25-OH VD), total serum alkaline phosphatase (TSAP), bone-specific alkaline phosphatase (BAP), urinary N-terminal telopeptide (NTX), urinary deoxypyridinoline (DPD), urinary calcium to creatinine ratio (Ca:Crea), insulin-like growth factor-1 SDS (IGF-1 SDS), nutritional vitamin and calcium intake, and screen-time (h).