Table 3.

Frequency of aberrant findings suggesting impaired bone health.

	BPH score items	Fraction of patients affected	Percentage of patients affected
Elevated PTH	•	18/122	14.8
Elevated or decreased TSAP/ BAP	•	43/128	33.6
Elevated or decreased DPD/NTX	•	10/98	10.2
Elevated or decreased Osteocalcin	•	11/79	13.9
Decreased urinary Ca excretion	•	3/118	2.5
Pathological fractures	•	8/121	6.6
Low BMD (DXA Z/HAZ < −2)	•	5/55	9.1
Bone pain (Knee or Back)	•	37/118	31.3
Osteonecrosis		16/128	12.5
Fractures of long bones		26/120 (4x2, 3x3)	15.9
25-OH VD deficiency (<20ng/ml)		89/124	71.8
Severe 25-OH VD def. (<10ng/ml)		43/124	34.7

Number and percentage of patients affected by altered parameters of calcium metabolism, bone metabolism, or notable clinical findings are displayed. For the assessment of the calcium metabolism, the following parameters were used: decreased calcium excretion in the urine (Ca:Crea ratio <0.01 mg/mg). For the assessment of bone metabolism, the following parameters were used: elevated levels of urinary N-terminal telopeptide (NTX) or urinary deoxypyridinoline (DPD), elevated total serum alkaline phosphatase (TSAP) and/or bone-specific alkaline phosphatase (BSAP) and elevated PTH. Bone-related pain in form of knee pain associated with exercise and recurrent back pain in the last month as well as the history of fractures of long bones was also included. “•” indicates a variable which is included in the BPH score.