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. 2020 Aug 26;8:827. doi: 10.3389/fcell.2020.00827

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Copyright © 2020 Li, Wang, Zhang, Sun, Shi and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relative circ-0016068 expression levels in prostate cancer. (A) Heatmap of differentially expressed circRNAs including circ-0016068 in prostate cancer tissue and paired non-tumor tissue counterparts. (B) RNase R digestion. Data represent the mean ± SD. (C) Sanger sequencing. (D) circ-0016068 is elevated in prostate cancer tissues. (E) Relative expression of circ-0016068 in prostate cancer cell lines compared to that in RWPE-1 cells by qRT-PCR. (F) Associations between circ-0016068 and the overall survival of prostate cancer patients were assessed using the Kaplan–Meier survival curve and log-rank test. *p < 0.05; **p < 0.01; ***p < 0.001.