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. 2020 Aug 26;8:827. doi: 10.3389/fcell.2020.00827

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Copyright © 2020 Li, Wang, Zhang, Sun, Shi and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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circ-0016068 promotes the tumor growth and lung metastasis in vivo. (A) Xenograft tumors in a mouse model of prostate cancer. (B) Tumor volumes of the circ-0016068 and sh-NC treatment groups. (C) Tumor weights. (D,E) circ-0016068 knockdown hinders the epithelial-to-mesenchymal transition (EMT) of prostate cancer cells and reduces BMI-1 expression in vivo. (F) circ-0016068 knockdown reduces the expression of BMI-1 and Ki67 in the xenograft tumors of a mouse model of prostate cancer. (G) circ-0016068 knockdown inhibits lung metastasis in a mouse model of prostate cancer metastasis; **p < 0.01; ***p < 0.001.