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. 2020 Aug 26;8:795. doi: 10.3389/fcell.2020.00795

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Copyright © 2020 Wang, Wang, Zhang, Zhang, Dai, Zhang, Feng and Cheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PTX3 affects cells viability and negatively modulate cell autophagy. (A) Cells proliferation ability is evaluated by CCK8 assay at 24 h, 48 h, and 72 h after interfering the expression of PTX3. (B) Western bolt illustrated autophagy related proteins, beclin1 and LC3B, are upregulated when PTX3 expression is inhibited. (C) The autophagy flux assay suggests the transition from LC3B-I to LC3B-II is inhibited when silenced PTX3 expression. (D) U87 MG cells are stained with DAPI (blue) and LC3B (green). Images are captured by laser confocal microscope (×400). (E) The colony-forming assay supports cells viability is inhibited by silencing PTX3 expression. NS, no significantly statistical; *P < 0.05; **P < 0.01; ***P < 0.001.