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. 2020 Aug 26;11:2053. doi: 10.3389/fmicb.2020.02053

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Copyright © 2020 Fang, Tang, Yang, Alalaiwe, Yang, Tseng and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Determination of the antifungal activity of naphthofuranquinone derivatives against planktonic drug-resistant C. albicans: (A) the chemical structures of naphthofuranquinones; (B) time-killing curves of 5-FC, fluconazole, and naphthofuranquinones; (C) zone of inhibition measured from agar diffusion assay; (D) the planktonic live/dead C. albicans strains treated by the agents at 23.5 μM viewed under fluorescence microscopy; and (E) the survival rate of C. albicans measured by flow cytometry according to Supplementary Figure S2. All data are presented as the mean of three experiments ±SD. ***p < 0.001, **p < 0.01, *p < 0.05.