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. 2020 Aug 26;11:2053. doi: 10.3389/fmicb.2020.02053

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Copyright © 2020 Fang, Tang, Yang, Alalaiwe, Yang, Tseng and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Determination of antifungal activity of naphthofuranquinone derivatives against biofilm and intracellular drug-resistant C. albicans: (A) C. albicans CFU outside and inside the biofilm; (B) the survival rate of keratinocytes and macrophages treated by 5-FC, fluconazole, and naphthofuranquinones measured by MTT assay; (C) the intracellular C. albicans CFU inside keratinocytes after treatment of 5-FC, fluconazole, and naphthofuranquinones; and (D) the intracellular C. albicans CFU inside macrophages after treatment of 5-FC, fluconazole, and naphthofuranquinones. All data are presented as the mean of three experiments ±SD (biological triplicate). ***p < 0.001, **p < 0.01.