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. 2020 Aug 26;11:2053. doi: 10.3389/fmicb.2020.02053

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Copyright © 2020 Fang, Tang, Yang, Alalaiwe, Yang, Tseng and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Skin tolerance examination of mouse skin by a 5-day treatment of topically applied TCH-1140: (A) the skin surface of mice viewed under handheld digital magnifier; (B) TEWL of mouse skin after treatment of 5-FC or TCH-1140; (C) erythema (a*) of mouse skin after treatment of 5-FC or TCH-1140; (D) pH of mouse skin after treatment of 5-FC or TCH-1140; and (E) histological observation of mouse skin biopsy stained by H&E. All data are presented as the mean of six experiments ±SD.