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. 2020 Aug 26;11:2081. doi: 10.3389/fimmu.2020.02081

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Copyright © 2020 Halbgebauer, Karasu, Braun, Palmer, Braumüller, Schultze, Schäfer, Bückle, Eigner, Wachter, Radermacher, Resuello, Tuplano, Nilsson Ekdahl, Nilsson, Armacki, Kleger, Seufferlein, Kalbitz, Gebhard, Lambris, van Griensven and Huber-Lang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association of non-receptor tyrosine-protein kinase 1 (TNK1)-mediated kidney injury with systemic inflammatory markers. Correlation analyses were performed for plasma values of TNK1 with parameters related to hemorrhagic shock (HS), inflammation, and kidney dysfunction in severely injured patients. The numbers of applied red blood cell concentrates (RBC) during the first 24 h were significantly correlated with plasma TNK1 5 days (A) and 10 days after trauma (B). Similarly, early levels of interleukin 6 (IL-6, 8 h after injury) significantly correlated with TNK1 5 days (C) and 10 days after trauma (D). The plasma kidney injury marker neutrophil gelatinase-associated lipocalin (NGAL) was significantly correlated with TNK1 levels on day 5 (E). Furthermore, plasma creatinine 24 h after injury was associated with TNK1 on day 10 (F). r, Pearson correlation coefficient.