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. 2020 Sep 8;10:14786. doi: 10.1038/s41598-020-71775-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation matrix of genes involved in the MHC-II antigen presentation pathway in GC subtypes. Heatmap of Spearman correlation analysis of mRNA expression of the indicated MHC-II pathway genes in EBVaGC (A). Comparisons with EBV genes reported to antagonize interferon-γ response are also shown. Spearman correlations between mRNA levels for IFNG and MHC-II pathway genes are also shown for the CIN (B), GS (C), and MSI (D) subtypes. Numbers in boxes indicate Spearman’s rank correlation coefficient of analyzed gene pairs and p-values. Figure was generated using the ggplot2 package in RStudio (version 1.2.1335; https://rstudio.com) and final figure layouts were adjusted with Adobe Illustrator (version CS6).

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