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. 2020 Sep 8;10:14776. doi: 10.1038/s41598-020-71767-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Tau pathology decreased in the hippocampus of EpoD-treated mice. (a,b) Representative western blot and quantitative analysis of the phospho-tau ratio (AT8/TAU46) from APP/PS1^Veh (n = 4) and APP/PS1^EpoD (n = 7) mice. β-Actin was used as the loading control. For quantification, ratio was referred to vehicle group. The ratio of phospho-tau/total tau was significantly reduced in treated mice (t test, *p < 0.05). Uncropped blots are shown in Supplementary Fig. S7. (c) AT8-positive dystrophies (arrows) were located surrounding Aβ plaques (Congo red, asterisk). Quantitative analysis (d) showed a significant decrease in the numerical density (ND) of AT8-positive dystrophic neurites (t test, *p < 0.05) in CA1 region from EpoD (c2) compared to vehicle mice (c1). so stratum oriens, sp stratum pyramidale, sr stratum radiatum. Scale bars: (c1) and (c2) 200 μm; insets 20 μm.