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. 2020 Sep 8;10:14776. doi: 10.1038/s41598-020-71767-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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EpoD treatment reduced Aβ pathology in APP/PS1 hippocampus. (a) Extracellular Aβ accumulation was assessed by both Aβ42 immunohistochemistry (a1,a2) and Thioflavin-S staining (a3,a4) for fibrillary plaques in the CA1 subfield. Insets show higher magnifications of stained amyloid plaques. (b) Quantitative analyses demonstrated a significant reduction of Aβ42 deposition in CA1 region (t test, *p < 0.05) of EpoD mice (n = 7) in comparison to vehicle group (n = 4). (c) Similarly, Thio-S loading was also found to be reduced in the hippocampus of EpoD treated mice (t test, *p < 0.05). (d) The numerical density (ND) of plaques did not change, but plaque size (e) was significantly smaller in EpoD group (t test, **p < 0.01). slm stratum lacunosum-moleculare, so stratum oriens, sp stratum pyramidale, sr stratum radiatum. Scale bars: (a1–a4) 200 μm; insets 20 μm.