Figure 3.
(A) Heatmap showing the Wald β’s of the associations between microbiome SNPs and health and disease outcomes, and continuous outcomes. Only significant associations (P value < 4.63·10−6) are shown. BMI body mass index, COPD chronic obstructive pulmonary disease, HDL high density lipoprotein, MAF minor allele frequency. (B) Heatmap showing the inverse variance weighted random effects β’s of the associations between the genetically determined increase of bacteria (family, genus and species level if possible) and health and disease outcomes, and continuous outcomes. Please note that the inverse variance weighted random effects β’s are in some cases liberal, considering the Rucker framework indicated unbalanced horizontal pleiotropy in the estimates as indicated by a significant (P < 0.05) Q–Q′ (and thus the MR-Egger estimate to be a better fit, please see Supplementary Table 5 for these results). BMI body mass index, COPD chronic obstructive pulmonary disease. # indicates suggestively significant.