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. 2020 Sep 8;11:4454. doi: 10.1038/s41467-020-18256-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — P14-Nr4a1-GFP cells were adoptively transferred into mice 1 day prior high dose LCMV clone 13 infection. Animals were sacrificed at various time points. a Examples of flow cytometry plots showing expression of Nr4a1-GFP and PD-1 in P14 cells (gated on alive single CD8⁺ CD45.1⁺ cells) isolated from the spleen of naive or chronically infected mice at various days post infection (dpi). Kinetics of GFP frequency b and GFP median c of P14-Nr4a1 GFP⁺ cells. d Nr4a1-GFP expression in P14 cells isolated from different tissues 21 dpi compared to the signal observed in activated cells isolated from the spleen 1 dpi. Full circles b, c and bar plots d represent mean ± SD. Empty circles b, c show individual data points. One of two experiments is shown (n = 2 mice for 1 to 3 dpi and 3 mice for 7 to 28 dpi). Each dot represents an individual mouse. See also Supplementary Fig. 1. Source data are provided as a Source Data File.