Table 4.
Effect of UDCA on the concentration of inflammatory mediators in liver tissue in the prevention and treatment of cholestasis-induced by LPS in rats.
| Groups | TNF-α Mean ± SD |
IL-1α Mean ± SD |
IL-4 Mean ± SD |
|---|---|---|---|
| Control group (n=12) | 37.40 ± 2.47b,c | 714.60 ± 73.32b | 625.60 ± 124.25 |
| UDCA group (n=12) | 39.60 ± 7.42b | 700.90 ± 54.25b | 600.80 ± 100.57 |
| LPS group (n=12) | 75.63 ± 3.72a | 898.50 ± 63.56 | 804.25 ± 61.01 |
| Treatment group (n=12) | 62.83 ± 9.20a | 851.33 ± 130.38 | 851.67 ± 51.00 |
| Prevention group (n=12) | 55.38 ± 13.15b | 832.63 ± 80.01 | 749.63 ± 89.55c |
Data are presented as mean ± S.D.
a
Significant change compared to control at P < 0.05.
b
Significant change compared to LPS group at P < 0.05.
c
Significant change compared to treatment group at P < 0.05.