Figure 3.

Comparison of the Lipid Metabolism-Related Indicators of T2D Models of WT, KL^+/−, and TgKL Mice

WT DM, KL^+/− DM, and TgKL DM were fed with a HFD for 8 weeks (n = 8/group). (A–E) Serum lipid profiles (TC, HDL, LDL, and TG) (A), LW/BW (B), serum ALT and AST levels (C), hepatic lipid contents (TG, TC) (D), and NEFA (E) of the three groups were determined. (F) Oil red O staining of liver sections from the three groups and HG-FFA-treated L02 cells with overexpression of sKL or not. Scale bar, 50 μm. (G and H) mRNA levels of genes related to lipogenesis, fatty acid uptake, and fatty acid oxidation in livers of the three groups (G) and HG-FFA-treated L02 cells (H). For all statistical plots, the data are presented as the mean ± SD; ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.