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AAV DNA Distribution in the Liver at Different Time Points after i.v. Injection
At 5 days after i.v. injection, a massive amount of the AAV DNA accumulated in the nuclei, with spotty signals in the cytoplasm of hepatocytes. From 4 to 24 weeks after i.v. injection, the AAV DNA exclusively resided in the nuclei. Scale bars, 100 μm (for ×10 original magnification), 50 μm (for both ×20 and ×60 original magnification).
