Table 1.

Distribution Pattern of AAV after i.v. Injection

Organs	Distribution Pattern
Kidney	highly accumulated in the glomeruli; scattered in the medulla; no viral DNA is visible in the Bowman’s capsule
Spleen	accumulated in the B cell-dominant areas of the white pulp; scattered in the red pulp
Lymph node	accumulated in the B cell-enriched cortical lymphoid nodules; scattered in the interfollicular zone
Testis	confined in the interstitium, and Leydig cells transduced; no viral DNA in seminiferous tubules
Ovary	scattered in central medulla and corpus luteum; thecal cells transduced; no viral DNA in the layer of zona granulosa and the oocytes
Adrenal glands	highly concentrated in the zona fasciculata and scattered in the zona glomerulosa and the medulla
Pancreas	accumulated in the β cells of the islets
Bone marrow and bone	robust localization in the bone marrow, with a few positive signals in the cartilage bone
Lung	lung alveolar cells transduced by AAV
Salivary glands	acinar cells transduced by AAV
Brain	relatively homogeneous distribution is seen in the brain, with viral DNA localized in endothelial cells, neurons, microglia, and astrocytes