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. 2020 Aug 26;11:1870. doi: 10.3389/fimmu.2020.01870

Figure 4.

Figure 4

(A–D) Expression profile of inhibitory and stimulatory receptors as well as the transcription factors T-bet and eomes in COVID-19 and malaria patients. (A) Frequency of HLA-DR/CD38 on PD1−LAG-3−, PD1−TIM-3−, PD1+LAG-3+, and PD1+TIM-3+ CD8+ and CD4+ T cells in COVID-19 and malaria patients. (B) Frequency of CD69 on PD1−LAG-3−, PD1−TIM-3−, PD1+LAG-3+ and PD1+TIM-3+ CD8+ and CD4+ T cells in COVID-19 and malaria patients. (C) Frequency of T-bet and eomes in CD8+ and CD4+ T cells in healthy donors and COVID-19 and malaria patients. Representative dot plots of the T-bet and eomes frequency gated on either CD8+ or CD4+ T cells. (D) Frequency of T-bet and eomes in PD1−LAG-3− and PD1+LAG-3+ CD8+ and CD4+ T cells in COVID-19 and malaria patients. P-values were calculated by Wilcoxon test for paired analysis and Mann–Whitney test for unpaired analysis. P-values smaller than 0.05 were considered significant, where *, **, ***, and **** indicate p-values between 0.01 to 0.05, 0.001 to 0.01, 0.0001 to 0.001 and <0.0001 respectively.