Table 1.
Demographic details extracted from the studies included in the analysis.
| S No | Studies | Year of pub | Country & Ethnicity | Population | Type of study | Method | Unit analyzed | HWE tested | No of cases | Mean age | No of controls | Mean age of controls | Matching bet case &Controls |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Einisman et al [25] | 2015 | Chile American |
Hospital based | Case control | PCR | Genotype | Not specified | 75 | 9.1yr (6 -15y) | 227 | 10.3 (2–12 yr) | Yes |
| 2 | Fawzy et al [26] | 2018 | Egypt Egyptian |
Hospital | Case control | RT PCR analysis | Genotype | Yes | 96 | 10 | 96 | 7–14 yrs | yes |
| 3 | Hou et al [27] | 2017 | China Asians |
Hospital | Case control | PCR- RFLP | SNP | Not specified | 70 | 8.84 +/- 3.21 | 70 | 8.04+/- 3.01 | yes |
| 4 | Hutchinson et al [28] | 2018 | Ireland European |
Hospital | Case control | RFLP | Genotype | Yes | 44 | 8.7 | 55 | Mean age not mentioned | no |
| 5 | Iordanidou et al [29] | 2014 | Greece European |
Hospital | Case control | PCR | Gene | Yes | 127 | 8.4+/- 0.2 | 91 | 9.6+/- 1.04 | Yes |
| 6 | Ismail et al [30] | 2013 | Egypt Egyptian |
Hospital Based | Case control | PCR RFLP | SNP | No | 51 | 8.6 | 33 | 7.8 | Yes |
| 7 | Leung et al [17] | 2015 | Hongkong Asians |
Hospital | Case control | Taqmann (PCR amplification) | SNP | Yes | 914 | 11+/- 0.4 | 1231 | 13.7 +/- 4.5 | Yes |
| 8 | Kilic et al [31] | 2019 | Turkish European |
Hospital | Case control | RFLP | SNP | YES | 100 | 9.5+/- 2.8 | 80 | 9.5+/-2.5 | YES |
| 9 | Maalmi et al [32] | 2013 | Tunisia African |
Population | Case control | PCR RFLP | Genotype | Yes | 155 | 9.1 (4 16yrs) | 225 | 9.5 (2–16yrs) | Yes |
| 10 | Munkhbayarlakh et al - Taiwan [33] | 2019 | Taiwan Asian |
Hospital | Case control | PCR amplification (MassARRAY) | SNP | Yes | 94 | 7.77+/- 4.09 | 129 | 28.11+/- 9.67 | no |
| 11 | Munkhbayarlakh et al - Mongolian [33] | 2019 | Mongolian Asian |
Hospital | Case control | PCR Amplification (MassARRAY) | SNP | Yes | 115 | 11.94+/- 10.28 | 256 | 27.75+/- 13.16 | No |
| 12 | Nabih et al [34] | 2014 | Egypt Egyptian |
Community | Case control | PCR | Genotype | Yes | 180 | 7.98+/-3.22 | 180 | 8.5+/- 2.22 | YES |
| 13 | NavasNazario et al [35] | 2015 | Yale European |
Community | Case control | PCR | Genotype | Yes | 81 | 5.8 | 247 | 5.6 | Yes |
| 14 | Papadopoulou et al [36] | 2015 | Cypriot European |
Community | Case control | PCR | Genotype allele | Yes | 190 | 16.9 (16–18year) | 671 | 17 (16–18yrs) | yes |
| 15 | Pillai et al [37] | 2011 | America African American |
Hospital | Case control | PCR | SNP | Yes | 139 | 11.2 (6-17y) | 74 | 11.8 (6-17y) | Yes |
| 16 |
Santos et al [38] |
2018 |
Brazil |
Hospital |
Observational, Case control |
PCR |
Promoter region |
Not specified |
60 |
8.7+/-2.5 |
17 |
10.8 = /- 2.2 |
yes |
| Studies based on family based analysis of transmission | |||||||||||||
| 1 | Bosse et al [15] | 2009 | Canada Canadian |
Family Based | FBAT | PCR | SNP | Yes | 1064 probands 210 | 17.6 | Not specified | 48.3 | No |
| 2 | Poon et al [13] | 2004 | Quebec Canadian |
Community | FBAT | FBAT | Genes &SNP | Yes | 570 subjects 223 probands | 16 (2–46yrs) | 569 | 48 (3-96y) | Not matched |
| 3 | Raby et al [12] | 2004 | America Americans |
Community | FBAT | FBAT | Genes | Yes | 1041 children 582 complete family | Girls 8.2 y boys 8.1 y | Not mentioned | 30 -55y | NO |
| 4 | Wjst et al [16] | 2006 | Germany European |
Population | Family based | PCR RFLP | Genotype | Yes | 210 families | 13.6 | 131 | Among families | No |
| 5 | Volmert et al [39] | 2004 | Germany European |
Community | FBAT | PCR | SNP | Not specified | 176 families with 352 parents 411 children | 10.7+/- 3.8 | 11.5+/- 4.3 | Yes | |
(Abbreviation foot note - HWE – Hardy-Weinberg Equilibrium, PCR – Polymerase chain reaction, RFLP – Restriction Fragment Length Polymorphism, FBAT – Family Based Analysis of transmission, SNP- Single nucleotide polymorphism, RT – Reverse transcriptase).