Table 4.
SNPs analyzed in various studies in Vitamin D associated genes that had significant association with children with asthma.
| Gene analysed | No of studies | Name of the study | SNP analysed | Type of analysis | Significance (p value) |
|---|---|---|---|---|---|
| CYP27A1 | 2 | Leung et al [17] | rs645163 | Logistic regression Additive Dominant |
Significant (p-0.018) Significant (0.022) |
| Bosse et al [15] | rs4674338 | FBAT | No association | ||
| CYP2R1 | 5 | Bosse et al [15] | rs11023774 | FBAT | Significant (p -0.017) |
| Pillai et al [37] | rs10766197 | Homozygous minor | Significant (p-0.044) | ||
| Wjst et al [16] | Several SNPs | Case control | Transmission present | ||
| Leung et al [17] | Several SNP | Case control | No association | ||
| Nazario et al [35] | Several SNP | Details not known | No association | ||
| CYP27B1 | 3 | Leung et al [17] | rs1048691 rs464638 rs4646536 |
Logistic regression & additive model | Significant (p-0.041) No significant association |
| Wjst et al [16] | rs238532, rs2072052, rs1048691, rs4646537, rs4646536, rs703842 |
FBAT | No association | ||
| Bosse et al [15] | FBAT | No association | |||
| CYP24A1 | 3 | Bosse et al [15] | rs8124792 rs2248359 rs927650 rs912505 |
FBAT | Significant (p - 0.030) Significant (p -0.032) No association |
| Wjst et al [16] | rs2244719 rs2296241 rs2248137 rs2762943 rs2248359 rs2426496 |
Transmission significance | No significance No significance p-0.0046 p-0.0256 p -0.0158 no significance |
||
| Pillai et al [37] |
rs2296241 rs2248137 rs2248359 rs17219315 |
Case control | Associated with decreased asthma control | ||
| GC | Ismail et al [30] | rs282679 | Case control Allele GG/TT GT/TT |
Significant OR 2.68 (1.36,5.28) Significant (p -0.04) Significant (p -0.08) |
|
| Leung et al [17] | rs2282679 rs4588 rs7041 rs222020 rs1155563 rs2298849 |
Case control | Not significant Not significant Significant Not significant Not significant Not significant |
||
| Wjst et al [16] | rs222040 rs7041 rs221999 |
FBAT Transmission approach |
0,0163 0,0249 |
||
| Nazario et al [35] | rs 7041 rs4588 |
Wild type allele Protein variant |
Significant association (p < 0.001 | ||
| Fawzy et al [26] | rs 7041 rs 4588 |
Allelic Codominant recessive Dominant Allelic Codominant Recessive Dominant |
3.08 (2.03,4.69) p < 0.0001 11.4 (4.26,30.8) p < 0.0001 10.7 (4.26,26.9) p < 0.0001 2.30 (1.25,4.23) p < 0.0001 0.44 (0.27,0.72) p < 0.001 0.39 (0.21, 0.75) p -0.0047 0.42 (0.14,1.27) p – 0.120 0.37 (0.20,0.68) p – 0.041 |
||
| Bosse et al [15] | 2 SNP | Was not included in analysis |
Abbreviation – SNP – Single nucleotide polymorphism, FBAT – Family Based analysis of transmission. The polymorphisms given in bold has been analysed & documented by several authors whereas those not in bold have been analysed only by that author.