Fig. 2.

The relatonship between plasma BAIBA concentration and insulin secretory function in humans. Panel A: BAIBA (identified and measured by metabolomic profiling) was measured in plasma samples collected from N = 10 non-diabetic individuals following an overnight fast (non-diabetic; white circles) and after 24-h of exposure to acute experimental hyperglycemia (non-diabetic 24 h; grey circles), and following an overnight fast in N = 10 age- and BMI-matched individuals with type 2 diabetes (T2DM; black circles). Panel B: Insulin secretory function (insulin secretion rate divided by plasma glucose) was also measured in the same subjects. Panel C: the relationship between plasma BAIBA concentrations and insulin secretory function. Individual subject data points are plotted on each panel. Lines on panels A and B represent mean averages ± SEM.