Presurgical staging with CEDM of a 60-y-old patient with an invasive ductal carcinoma in the upper-central quadrant of the right breast diagnosed by VAB. a, b, craniocaudal low energy and recombined CEDM images; aI, bI mediolateral oblique CEDM low-energy and recombined images. The CEDM examination showed the presence of a copious post biopsy hematoma at the site of the index lesion which generated a characteristic artifact called “negative contrast enhancement” or “eclipse sign”, thus preventing correct visualization of the BC and interpretation of the images. (c) US examination confirmed the presence of a copious hematoma with a post biopsy marker in the context, in the site of the index lesion. A false negative CEDM case.