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. 2020 Aug 12;28:102376. doi: 10.1016/j.nicl.2020.102376

Table 1.

Description of patients and copy-draw sessions analyzed. Unless indicated otherwise, DBS was performed with a pulse width of 60 μs and frequency of 130 Hz. The STN contralateral to the dominant hand was stimulated during DBS-on, unless bilateral stimulation was applied, which is indicated. Medication intake times are provided relative to the experiment start. Scores of unified PD rating scale part III were obtained—unless indicated otherwise—in medication off state and several days prior to the implantation surgery. Tremor (T), bradykinesia (B), and rigor (R) scores obtained under DBS-on are given relative to this DBS-off baseline, ranging from 0 (no improvement), to +3 (complete symptom suppression), according to the average of following hand motor items of the unified PD rating scale part III: 3 (rigor); 4, 5 and 6 (bradykinesia); 15 and 16 (tremor). n/a marks unavailable information. Please refer to the main text for an explanation of the session codes.

Patient Session Age Sex Medication DBS parameters Trial
duration
N trials Preimplantation
UPDRS-Part III
T B R
S1 +2 55 M normal acting l-Dopa at +26 min
and fast acting l-Dopa at +43 min
3 mA 7.5 s 144 25 (med-on) 0 +2 +2
c fast acting l-Dopa at +15 min 2.4 mA, bi 216 n/a
S2 +2 54 F medication off 6 mA 6 s 144 18 +2 +2 +2
c 168 +3 0 +2
S3 c 56 M medication off 6 mA 7.5 s 120 41 n/a
S4 +2 retarded l-Dopa at −150 min 6.5 mA 6 s 168 23 0 0 +1
+3 44 M retarded l-Dopa at −330 min 5 mA 168 0 0 +1
c normal acting l-Dopa combined with
COMT-Inhibitor (Entacapone) at −210 min
3.5 mA, 30 μs 156 0 +1 +2
S5 +2 retarded l-Dopa at −300 min 6.5 mA 6 s 144 33 0 +1 +1
+3 69 M retarded l-Dopa at −210 min 6.5 mA 144 +1 +1 +2
c normal acting l-Dopa −660 min 6.0 mA 192 0 +1 +1
S6 +2 63 M retarded l-Dopa at −330 min 3 mA 9 s 144 35 +1 +2 0
c medication off 3.5 mA 192 0 +2 +1
S7 +2 n/a 4.5 mA 9 s 168 34 0 0 +2
+3 55 M retarded l-Dopa at −330 min 5 mA 6 s 168 n/a
c normal acting l-Dopa −660 min 3.5 mA 7.5 s 192 0 +2 +2