Table 2.
Effects of C. edulis on brain MDA, glutathione, catalase, AChE activity, and protein concentration of Scopolamine-treated mice.
| Doses (mg/kg) | MDA (mmol/g) | Glutathione (mmol/g) | Catalase (mmol H2O2/mg) | AChE (mol/min/g) | Protein (g/dl) | |
|---|---|---|---|---|---|---|
| Control | 63.61 ± 3.56 | 4.16 ± 0.36 | 290.56 ± 14.34 | 1.53 ± 0.04 | 5.96 ± 1.23 | |
| Scopo | 1 | 105.46 ± 2.67### | 1.63 ± 0.10## | 108.58 ± 4.65### | 2.45 ± 0.10## | 5.85 ± 0.45 |
| C. edulis | 62.8 | 94.53 ± 5.06 | 2.16 ± 0.20 | 145.45 ± 7.80∗∗ | 2.12 ± 0.12 | 6.31 ± 0.67 |
| 157 | 76.76 ± 3.14∗ | 3.86 ± 0.16∗ | 251.44 ± 32.55∗∗∗ | 1.78 ± 0.07∗ | 6.04 ± 0.11 | |
| 314 | 68.69 ± 3.87∗∗ | 4.19 ± 0.27∗ | 274.36 ± 8.78∗∗∗ | 1.47 ± 0.09∗∗ | 6.12 ± 0.23 | |
| 628 | 64.88 ± 4.47∗∗∗ | 4.29 ± 0.09∗∗ | 325.00 ± 18.89∗∗∗ | 1.40 ± 0.11∗∗ | 5.96 ± 0.78 | |
| Donepezil | 5 | 60.38 ± 6.89∗∗∗ | 4.47 ± 0.12∗∗ | 423.60 ± 10.14∗∗∗ | 1.31 ± 0.08∗∗∗ | 6.29 ± 1.04 |
Each value represents the mean ± SEM (n = 5). The level of MDA increases and the antioxidant enzyme level decreases for the Scopolamine group (##p < 0.01, ###p < 0.001 vs. control), and the administration of C. edulis aqueous extract decreases the level of MDA by increasing the level of antioxidant enzymes (∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001 vs. Scopo). One-way ANOVA followed by the Tukey multiple comparison test. Scopo: Scopolamine.