Table 1A.
Co-clinical T1w and T2w image descriptors for sensitivity to noise and resolution.
| MR Seq. | Metric | SNR (in dB) | Estimated noise level | 3D tumour |
2D slice |
|||
|---|---|---|---|---|---|---|---|---|
| Tumour volume (mm3) | Number of voxels | Largest cross section (mm3) | Number of voxels in largest cross section area | |||||
| Clinical* | T1w (N=25) | Range | 18.9– 45.4 | 0.20 – 0.68 | 1,182 – 43,309 | 268 – 2,837 | 366 – 4,600 | 93 – 1,394 |
| Avg±SD | 30.6 ± 07.6 | 0.37 ± 0.13 | 6,773 ± 8155 | 1,259 ± 760 | 1,229 ± 834 | 305 ± 254 | ||
| Median | 29.6 | 0.37 | 4725 | 984 | 1129 | 244 | ||
| 95% CL | 03.2 | 0.05 | 3366 | 321 | 344 | 105 | ||
| T2w (N=25) | Range | 21.3– 74.0 | 0.25 – 0.93 | 1,873 – 4,4691 | 832 – 23,513 | 518 – 4,567 | 230 – 2,403 | |
| Avg±SD | 35.7 ± 11.7 | 0.57 ± 0.13 | 7,603 ± 8360 | 3,592 ± 4,424 | 1,387 ± 820 | 643 ± 435 | ||
| Median | 33.1 | 0.57 | 5305 | 2244 | 1226 | 527 | ||
| 95% CL | 4.9 | 0.05 | 3451 | 1826 | 339 | 179 | ||
| Preclinical⁎⁎ | ||||||||
| High Res | T1w (N=11) | Range | 17.0– 64.4 | 0.69 – 2.56 | 174 – 467 | 11,362 – 29,896 | 33 – 83 | 2,157 – 5,287 |
| Avg±SD | 33.1 ±12.7 | 1.38 ± 0.57 | 317 ± 109 | 20,525 ± 7142 | 49 ± 15 | 3,184 ± 970 | ||
| Median | 33.1 | 1.18 | 350 | 22885 | 42.4 | 2771 | ||
| 95% CL | 8.5 | 0.38 | 73 | 4798 | 10 | 652 | ||
| T2w (N=11) | Range | 19.4– 65.4 | 0.98 – 2.46 | 174 – 456 | 11,362 – 29,201 | 33 – 80 | 2,157 – 5,119 | |
| Avg±SD | 33.8 ± 13.3 | 1.5 ± 0.43 | 309 ± 114 | 20,037 ± 7,483 | 48 ± 15 | 3,138 ± 978 | ||
| Median | 33.0 | 1.35 | 350 | 22885 | 42 | 2771 | ||
| 95% CL | 8.1 | 0.29 | 77 | 5027 | 10 | 657 | ||
| Med Res | T1w (N=25) | Range | 17.3– 63.7 | 0.45 – 1.95 | 75 – 438 | 1,447 – 7,175 | 20 – 61 | 372 – 992 |
| Avg±SD | 33.5± 11.6 | 0.96 ± 0.33 | 245 ± 123 | 4,157 ± 1901 | 38 ± 13 | 651 ± 189 | ||
| Median | 30.9 | 0.96 | 198 | 3357 | 35 | 621 | ||
| 95% CL | 4.8 | 0.13 | 51 | 785 | 5 | 78 | ||
| T2w (N=25) | Range | 18.0– 52.2 | 0.51 – 1.59 | 64 – 436 | 1,234 – 7,141 | 17 – 61 | 320 – 992 | |
| Avg±SD | 32.78± 7.8 | 0.97 ± 0.22 | 241 ± 125 | 4,091 ± 1,931 | 37 ± 13 | 639 ± 189 | ||
| Median | 30.9 | 0.94 | 190 | 3518 | 34 | 591 | ||
| 95% CL | 3.3 | 0.09 | 51 | 797 | 5 | 78 | ||
| Low Res | T1w (N=6) | Range | 20.7– 65.5 | 0.47 – 1.69 | 172 – 442 | 706 – 1,809 | 37 – 72 | 150 – 294 |
| Avg±SD | 36.6± 16.7 | 0.79 ± 0.46 | 357 ± 96 | 1,464 ± 3393 | 55 ± 13 | 225 ± 54 | ||
| Median | 31.7 | 0.66 | 386 | 1583 | 59 | 243 | ||
| 95% CL | 17.6 | 0.48 | 101 | 412 | 14 | 57 | ||
| T2w (N=6) | Range | 19.6–63.9 | 0.36 – 1.21 | 172 – 442 | 706 – 1,809 | 37 – 72 | 150 – 294 | |
| Avg±SD | 35.2± 15.5 | 0.73 ± 0.29 | 358 ± 97 | 1,467 ± 395 | 55 ± 13 | 226 ± 54 | ||
| Median | 32.2 | 0.70 | 386 | 1583 | 60 | 246 | ||
| 95% CL | 16.3 | 0.31 | 101 | 415 | 14 | 57 | ||
⁎
Clinical image voxel size (x,y,z): T1 (1.0mm, 1.0mm, 3mm); T2w (0.76mm, 0.76mm, 3mm).
⁎⁎
Preclinical image voxel size (x,y,z): High Res T1w and T2w (0.125mm, 0.125mm, 1mm); Med Res T1w and T2w (0.25mm, 0.25mm, 1mm); Low Res T1w and T2w (0.5mm, 0.5mm, 1mm).