Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 3;20(5):194. doi: 10.3892/ol.2020.12056

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Perrone et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 3. — Morphological and immunohistochemistry diagnosis of large-cell carcinoma of the lung. (A) Hematoxylin and eosin staining documenting malignant large pleomorphic cells with a moderate to abundant amount of cytoplasm, vesicular nuclei, prominent nucleoli and necrosis. IHC staining of (B) TTF1 and (C) p40 revealed expression of the two markers on pneumocytes (TTF1) and basal cell (p40) only, thus supporting the diagnosis of large-cell carcinoma of the lung. The negativity of TTF1 and p40 precluded the diagnosis of lung adenocarcinoma or squamous cell carcinoma, respectively. Tumors lacked morphological and immunohistochemical evidence of glandular, squamous or neuroendocrine differentiation. (D) Programmed death-ligand 1 expression levels on the surface membrane of 55% of tumor cells. Magnification, (A-C) ×20 and (D) ×40. TTF1, transcription termination factor 1.