Table 1.

Nm23-H1 binding proteins and the pathway(s) regulated by the interaction

Protein	Regulated pathway	Phenotype	Isoform	Reference
Tiam1	Rac pathway	Rac1 inactivation	Nm23-H1	[68]
Ksr	Erk pathway	Ksr degradation	Nm23-H1	[11]
Rps3	Erk pathway	Ark pathway inactivation	Nm23-H1	[69]
Lbc	Rho GTPase pathway	Rho GTPase pathway inhibition	Nm23-H2	[70]
Rad	Ras pathway	Ras pathway inactivation	Nm23-H1	[71]
Dbl-1	cdc42	Cdc42 GTPase inhibition	Nm23-H1	[72]
ARF6	Endocytosis	E-cadherin-mediated edocytosis	Nm23-H1	[73]
STRAP	TGFβ pathway	p53-induced apoaptosis and cell cycle arrest	Nm23-H1	[74]
EBNA-1-3C	Transcriptional regulation	Increased MMP9 and αV integrin expression	Nm23-H1	[20]
ERα	Transcriptional regulation	Reduced cathepsin and Bcl-2 expression	Nm23-H1	[75]
ERβ	Transcriptional regulation	Increased estrogen-mediated transcription	Nm23-H2	[76]
RORaa	Transcriptional regulation	N/A	Nm23-H1, Nm23-H2	[77]
Oct-1	Transcriptional regulation	N/A	Nm23-H1	[78]
SET	Transcriptional regulation	Granzyme A-mediated cell death	Nm23-H1	[79]
Vimentin	Cytoskeleton modulation	Increased intermediate filaments density	Nm23-H1	[80]
Tubulin	Cytoskeleton modulation	N/A	Nm23-H1	[81]
Icap-1a	Cell adhesion	N/A	Nm23-H2	[82]
Plakoglobin	Cell adhesion	Increased protein stability	Nm23-H1, Nm23-H2	[83]
APE1	DNA repair	Increased APE1 endonuclease activity	Nm23-H1	[15]
Prune	Pro-metastasis	Increase cAMP-PDE prune activity	Nm23-H1	[84]
MDM2	p53 degradation	Inhibition Nm23 anti-motility ability	Nm23-H2	[85]
HPV 16E7	Cervical cancer	Ubiquitin-proteosome-dependent Nm23 degradation	Nm23-H1, Nm23-H2	[86]
GAPDH	Glycolytic pathway	Phosphoglycerate mutase activation	Nm23-H1	[87]
Aurora-A	Mitosis	N/A	Nm23-H1	[88]

^aThe interaction has been shown only by two-hybrid and GST pull down experiments