Table 2.
Ectopic expression of Nm23 in higH1y metastatic cancer cells reduced metastasis formation
| Tumor type | Origin | Cell line | Reduction in metastases (%) | Gene | Reference |
|---|---|---|---|---|---|
| Breast carcinoma | Human | MDA-MB-435 | 50–90 | Nm23-H1 | [89] |
| Breast carcinoma | Human | MDA-MB-435 | 40–100 | Nm23-H1, Nm23-H2 | [90] |
| Breast carcinoma | Human | MDA-MB-231- BAG | 40–50 | Nm23-H1, Nm23-H2 | [91] |
| Breast carcinoma | Rat | MTC/MTLn3 | 30–70 | Nm23-H1, Nm23-H2 | [92] |
| Breast carcinoma | Murine | 4T1 | 60–70 | Nm23-H1, Nm23-M1 | [23] |
| Melanoma | Murine | K-1735 TK | 58–96 | Nm23-H1 | [93] |
| Melanoma | Murine | B16-sublines | 54–90 | Nm23-M1, Nm23-M2 | [94] |
| Melanoma | Murine | B16F10 | 93 | Nm23-H1 | [95] |
| Melanoma | Human | 1205LU | 62 | Nm23-H1 | [15] |
| Melanoma | Murine | MelJuSo | 40–80 | Nm23-H1 | [96] |
| Colon | Murine | colon26 | 55 | Nm23-H2 | [97] |
| Colon | Human | HT-29 | 90 | Nm23-H1 | [98] |
| Oral squamous cell carcinoma | Human | LMF4 | 80–90 | Nm23-H2 | [25] |