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. 2020 Sep 8;3:496. doi: 10.1038/s42003-020-01227-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a RNA-sequence analyses of tissues from WT and Nrf2-KO mice in GC and FL groups. b Heatmap of expression levels of representative Nrf2-target genes in temporal bone (TpB), mandible bone (MdB), spleen (Spl), liver (Liv), epididymal white adipose tissue (eWAT), inter-scapular brown adipose tissue (iBAT), thymus (Thy), kidney (Kid), and brain cerebrum (Cbr) from WT and Nrf2-KO mice in GC and FL groups. c Expression levels of Nqo1 and Hmox1 genes in thymus from WT and Nrf2-KO mice in GC and FL groups. Data are presented as mean, and dots represent individual animals. n = 6 for GC_WT, FL_WT and GC_KO, and n = 5 for FL_KO, one-way ANOVA with Tukey–Kramer test. d Model for space stress response system by Nrf2 signaling.