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. 2020 Sep 8;10:14749. doi: 10.1038/s41598-020-71573-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Uptake of SGC-7901, MKN-45, MKN-28 derived exosomes by immune cell subpopulation. The percentage fluorescent signal of exosome uptake by immune populations in the bone marrow BM, spleen, and lung was analyzed post 48 h by flow cytometry after injection of DiD-labeled SGC-7901, MKN-45, MKN-28-derived exosomes (20 μg/mice) or PBS (control) in C57BL/6 mice. (A) Representative flow cytometric plots (left) and quantification (right) of distinct DiD⁺ population within CD45⁺ cells. (B–F), Frequency of the DiD⁺ subpopulation within macrophages (Mø; CD11b⁺/F4/80⁺, B), DCs (CD11C⁺/MHCII⁺, C), CD8 T cells (CD3⁺/CD8⁺, D), NK cells (NK1.1⁺/CD3⁻, E) and CD4 T cells (CD3⁺/CD4⁺, F). Results are presented as mean ± SEM and analyzed by ANOVA, *, P < 0.05, **, P < 0.01, ***, P < 0.001.